A20 20..20
نویسنده
چکیده
Two papers in the Journal this week focus on the potential impact of cannabis use on mental health outcomes. Di Forti et al (pp. 488–491) examined the risk of psychosis associated with use of high-potency cannabis. They found that individuals presenting with a first episode of psychosis were no more likely than local population controls to have ever taken cannabis but the former were more likely to have taken high-potency cannabis. Price et al (pp. 492–497) utilised data from a longitudinal study of men conscripted for military service in Sweden and found that although cannabis use was associated with an elevated risk of suicide, adjustment for markers of psychological and behavioural problems eliminated the association.
منابع مشابه
A20 (TNFAIP3) Deletion in Epstein-Barr Virus-Associated Lymphoproliferative Disorders/Lymphomas
A negative regulator of the nuclear factor (NF)-κB pathway, A20 (TNFAIP3), is inactivated in several types of lymphomas; particularly in diffuse large B-cell lymphoma (DLBCL), classical Hodgkin's lymphoma, and extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue. These findings suggest that the NF-κB activation is related to A20 inactivation. Recently, A20 inactivation has...
متن کاملAdes 27-9
In murine erythroleukemia (MEL) A20 cells (grown in 20 ng/ml adriamycin), mutation(s) producing 10-fold adriamycin (doxorubicin) resistance emerged via an unknown mechanism. Exposure of A20 cells to further stepwise increasing concentrations of ADR in combination with MDR modulators (PSC833 and verapamil) aimed to amplify the undetermined A20 mechanism while controlling P-glycoprotein (P-gp) ov...
متن کاملUbiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes.
Although enterocytes are capable of innate immune responses, the intestinal epithelium is normally tolerant to commensal bacteria. To elucidate the mechanisms of tolerance, we examined the effect of preexposure to LPS on activation of p38, c-Jun, and NF-kappaB in enterocytes by several inflammatory and stress stimuli. Shortly after the initial LPS challenge, enterocytes become tolerant to resti...
متن کاملExpression of A20 protein in prostate cancer tissues and its relationship with postoperative recurrence and survival
This study aimed to investigate the expression of A20 protein in prostate cancer tissues and its relationship with postoperative recurrence and survival. 86 patients with prostate cancer received surgery were collected as observation group, while 20 cases of benign prostatic hyperplasia were selected as control group in our hospital during June 2012 to June 2015. RT-PCR and immunohistochemistry...
متن کاملA 20 Inhibits Cytokine - induced Apoptosis and Nuclear Factor k B – dependent Gene Activation in Islets By Shane
Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease resulting from apoptotic destruction of b cells in the islets of Langerhans. Low expression of antioxidants and a predilection to produce nitric oxide (NO) have been shown to underscore b cell apoptosis. With this perspective in mind, we questioned whether b cells could mount an induced protective response to inflammation. Here...
متن کاملMolecular Basis for the Unique De - ubiquitinating Activity of the NF - κ B Inhibitor A 20
NF-κB activation in the TNF, IL-1 and Toll-like receptor pathways requires Lys63-linked nondegradative polyubiquitination. A20 is a specific feedback inhibitor of NF-κB activation in these pathways and possesses dual ubiquitin editing functions. While the N-terminal domain of A20 is a de-ubiquitinating enzyme (DUB) for Lys63-linked polyubiquitinated signaling mediators such as TRAF6 and RIP, it...
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